Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8762086 | 1.00 | KMT2A (0.54) | KMT2AMAPTMMP2TDP1SIGMAR1 | |
| SCHEMBL8763056 | 0.86 | POLB (0.50) | KMT2ATDP1SIGMAR1POLBALDH1A1 | |
| SCHEMBL8763062 | 0.86 | POLB (0.50) | KMT2ATDP1SIGMAR1POLBALDH1A1 | |
| SCHEMBL28648995 | 0.85 | TDP1 (0.51) | KMT2AMAPTTDP1GAAALDH1A1 | |
| SCHEMBL28669514 | 0.84 | ALDH1A1 (0.58) | KMT2AMAPTTDP1GAAALDH1A1 | |
| SCHEMBL28659822 | 0.84 | TDP1 (0.54) | KMT2AMAPTTDP1POLBALDH1A1 | |
| SCHEMBL17319526 | 0.83 | KMT2A (0.74) | KMT2AMAPTPOLBGAAALDH1A1 | |
| SCHEMBL12471703 | 0.83 | KMT2A (0.74) | KMT2AMAPTPOLBGAAALDH1A1 | |
| SCHEMBL28928244 | 0.83 | TDP1 (0.64) | KMT2AMAPTTDP1SIGMAR1POLB | |
| SCHEMBL28928246 | 0.83 | TDP1 (0.64) | KMT2AMAPTTDP1SIGMAR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652257-A | ANTICARCINOGENIC | MERCK & CO., INC. (US) | 1997-07-29 | — | — | US | disclosed |
| EP-0783517-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010034-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |