SCHEMBL8763095

SCHEMBL8763095

Cc1cccc(CC#N)c1CC#N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.35
KDM4E B2RXH2 2/20 0.33
TAAR1 Q96RJ0 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
EGFR P00533 1/20 0.33
SRC P12931 1/20 0.33
CYP1A2 P05177 2/20 0.32
CYP2A6 P11509 1/20 0.32
LMNA P02545 1/20 0.32
ENPP2 Q13822 1/20 0.32
CYP2C19 P33261 1/20 0.32
GRIA1 P42261 1/20 0.31
CACNG8 Q8WXS5 1/20 0.31
ATP4A P20648 1/20 0.31
ATP4B P51164 1/20 0.31
CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16888337 0.88 ALDH1A1 (0.38) ALDH1A1HPGDTSHRKDM4ETAAR1
SCHEMBL954804 0.87 TSHR (0.41) ALDH1A1TSHRKDM4ETAAR1TDP1
SCHEMBL28743970 0.82 ALDH1A1 (0.38) ALDH1A1HPGDTSHRKDM4ETAAR1
SCHEMBL31454409 0.82 ALDH1A1 (0.38) ALDH1A1HPGDTSHRKDM4ETAAR1
SCHEMBL3792645 0.81 ESR1 (0.41) ALDH1A1HPGDTSHRKDM4ETAAR1
Water SCHEMBL28641184 0.80 ALDH1A1 (0.47) ALDH1A1HPGDTSHRKDM4ETAAR1
SCHEMBL102904 0.80 ALDH1A1 (0.47) ALDH1A1HPGDTSHRKDM4ETAAR1
SCHEMBL31426960 0.80 ALDH1A1 (0.47) ALDH1A1HPGDTSHRKDM4ETAAR1
SCHEMBL28380698 0.80 ALDH1A1 (0.45) ALDH1A1HPGDKDM4ETDP1MEN1
SCHEMBL11114860 0.78 TAAR1 (0.38) ALDH1A1HPGDTSHRKDM4ETAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349195-B1 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC (US) 1997-05-21 EP disclosed
US-5629394-A ENDCAPPING ADDITION POLYMERS WITH NITROGEN FUNCTIONAL GROUPS WHICH CAN BE FURTHER DERIVATIZED EXXON CHEMICAL PATENTS INC (US) 1997-05-13 US disclosed
US-5444135-A Polymerization and functionalization with nitrogen-containing functional groups occur simultaneously EXXON CHEMICAL PATENTS INC. (US) 1995-08-22 US disclosed
US-5336745-A Terminally-substituted polymeric compositions from cationically polymerizable monomers and initiators EXXON CHEMICAL PATENTS INC. (US) 1994-08-09 US disclosed
US-5032653-A Catalysts EXXON CHEMICAL PATENTS, INC. (US) 1991-07-16 US disclosed
EP-0349195-A2 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC. (US) 1990-01-03 EP disclosed