SCHEMBL8763263

SCHEMBL8763263

O=CNCc1ccc(Cc2ccc(CNC=O)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADH1B P00325 1/20 0.67
ADH1C P00326 1/20 0.67
ADH1A P07327 1/20 0.67
ADH7 P40394 1/20 0.67
CYP3A4 P08684 2/20 0.38
TSHR P16473 2/20 0.38
ALOX5 P09917 1/20 0.36
ALDH1A1 P00352 4/20 0.36
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HPGD P15428 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
LMNA P02545 3/20 0.35
HTT P42858 2/20 0.35
KDM4E B2RXH2 1/20 0.35
KMT2A Q03164 2/20 0.35
TP53 P04637 1/20 0.34
CYP2C9 P11712 1/20 0.34
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8763196 0.92 ADH1B (0.76) ADH1BADH1CADH1AADH7ALOX5
SCHEMBL10404137 0.82 ADH1B (0.57) ADH1BADH1CADH1AADH7CYP3A4
SCHEMBL513192 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7CYP3A4
SCHEMBL17503962 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7TSHR
SCHEMBL3306571 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7ALDH1A1
SCHEMBL4633463 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7ALDH1A1
SCHEMBL1486309 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7CYP3A4
SCHEMBL5221625 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7ALDH1A1
SCHEMBL43651 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7CYP3A4
SCHEMBL26832960 0.81 ADH1B (0.61) ADH1BADH1CADH1AADH7TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349195-B1 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC (US) 1997-05-21 EP disclosed
US-5629394-A ENDCAPPING ADDITION POLYMERS WITH NITROGEN FUNCTIONAL GROUPS WHICH CAN BE FURTHER DERIVATIZED EXXON CHEMICAL PATENTS INC (US) 1997-05-13 US disclosed
US-5444135-A Polymerization and functionalization with nitrogen-containing functional groups occur simultaneously EXXON CHEMICAL PATENTS INC. (US) 1995-08-22 US disclosed