SCHEMBL8763786

SCHEMBL8763786

Cc1cccc(C(=O)OC(C)C)c1N

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.50
CA12 O43570 4/20 0.49
CA1 P00915 4/20 0.49
CA2 P00918 4/20 0.49
CA7 P43166 4/20 0.49
CA9 Q16790 4/20 0.49
CA14 Q9ULX7 4/20 0.49
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 2/20 0.45
CYP2D6 P10635 1/20 0.45
CYP19A1 P11511 1/20 0.45
MMP1 P03956 1/20 0.42
MMP2 P08253 1/20 0.42
MMP9 P14780 1/20 0.42
MMP12 P39900 1/20 0.42
CRHBP P24387 1/20 0.42
CRHR2 Q13324 1/20 0.42
PDK2 Q15119 1/20 0.42
PDCD1 Q15116 1/20 0.41
CD274 Q9NZQ7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2929420 0.84 NPC1 (0.51) NPC1CA12CA1CA2CA7
SCHEMBL31091512 0.83 CA12 (0.62) NPC1CA12CA1CA2CA7
SCHEMBL277670 0.82 NPC1 (0.56) NPC1CA12CA1CA2CA7
SCHEMBL17707768 0.81 NPC1 (0.49) NPC1CA12CA1CA2CA7
SCHEMBL15771342 0.81 NPC1 (0.49) NPC1CA12CA1CA2CA7
SCHEMBL17707767 0.81 NPC1 (0.49) NPC1CA12CA1CA2CA7
Hydrochloric Acid SCHEMBL29090149 0.81 NPC1 (0.51) NPC1CA12CA1CA2CA7
SCHEMBL5695945 0.81 HPGD (0.56) NPC1CA12CA1CA2CA7
SCHEMBL29003949 0.81 CA12 (0.59) NPC1CA12CA1CA2CA7
SCHEMBL228051 0.80 ALDH1A1 (0.58) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115181031-B Preparation method of 2-amino-5-chlorobenzoic acid derivative 江苏扬农化工股份有限公司 2024-03-15 CN disclosed
CN-115181031-A Preparation method of 2-amino-5-chlorobenzoic acid derivative 江苏扬农化工股份有限公司 2022-10-14 CN disclosed
CN-108883099-B Thiazolidinone compounds and use thereof 石全 2021-09-28 CN disclosed
EP-0511826-B1 Phosphosulfonate herbicides ROHM & HAAS (US) 1997-07-16 EP disclosed
US-5500405-A Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1996-03-19 US disclosed
US-5272128-A Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1993-12-21 US disclosed
EP-0511826-A2 Phosphosulfonate herbicides ROHM AND HAAS COMPANY (US) 1992-11-04 EP disclosed