Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 3/20 | 0.42 |
| ▸ | KDM4A | O75164 | 3/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.42 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.42 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167721 | 0.69 | PTPN11 (0.61) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL9311809 | 0.69 | KDM6B (0.39) | KDM6BKDM4AKDM4DKDM3BHIF1AN | |
| SCHEMBL16836639 | 0.68 | PTPN11 (0.60) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL668981 | 0.68 | PTPN11 (0.64) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL4462194 | 0.68 | PTPN11 (0.64) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL16603119 | 0.68 | TSHR (0.36) | TSHRMEN1KMT2ATDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9038246 | 0.68 | PTPN11 (0.60) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL10539639 | 0.68 | PTPN11 (0.64) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| Hydrochloric Acid SCHEMBL8154036 | 0.68 | PTPN11 (0.60) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL35210991 | 0.68 | PTPN11 (0.64) | PLA2G2ATP53TSHRPLA2G4BPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619182-B1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MAN CO LTD (JP) | 2016-11-09 | — | — | EP | disclosed |
| EP-3061751-A1 | PHARMACEUTICAL COMPOSITION | Eisai R&D Management Co., Ltd. (JP) | 2016-08-31 | — | — | EP | disclosed |
| CN-103097358-B | Pharmaceutical composition | EISAI R&D MAN CO LTD | 2015-04-08 | — | — | CN | disclosed |
| US-9000024-B2 | Pharmaceutical composition | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-07 | — | — | US | disclosed |
| US-20140155452-A1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-06-05 | — | — | US | disclosed |
| US-20130237578-A1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-12 | — | — | US | disclosed |
| EP-2619182-A1 | PHARMACEUTICAL COMPOSITION | Eisai R&D Management Co., Ltd. (JP) | 2013-07-31 | — | — | EP | disclosed |
| CN-103097358-A | Pharmaceutical composition | EISAI R&D MAN CO LTD | 2013-05-08 | — | — | CN | disclosed |
| WO-2012039972-A1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155452-A1 | PHARMACEUTICAL COMPOSITION | CYP3A5, CYP2C19, CYP3A7 | PLA2G2A 1454/4885TP53 3778/4885TSHR 4234/4885 |
| US-20130237578-A1 | PHARMACEUTICAL COMPOSITION | CYP3A5, CYP2C19, CYP3A7 | PLA2G2A 1454/4885TP53 3778/4885TSHR 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.