Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28577000 | 0.88 | CYP2C19 (0.50) | CYP2C19CYP1A2CYP2C9TSHRCHRM3 | |
| SCHEMBL28576999 | 0.88 | CYP2C19 (0.50) | CYP2C19CYP1A2CYP2C9TSHRCHRM3 | |
| SCHEMBL10973157 | 0.86 | CYP2C9 (0.50) | CYP2C19CYP1A2CYP2C9TSHRLMNA | |
| SCHEMBL11294582 | 0.84 | CYP2C19 (0.47) | CYP2C19CYP1A2CYP2C9TSHRCHRM3 | |
| SCHEMBL8804531 | 0.81 | CYP2C19 (0.44) | CYP2C19CYP1A2CYP2C9TSHRCHRM3 | |
| SCHEMBL10358475 | 0.81 | TSHR (0.50) | CYP2C19CYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL10667123 | 0.81 | CYP1A2 (0.44) | CYP2C19CYP1A2CYP2C9TSHRCYP2D6 | |
| SCHEMBL9661863 | 0.81 | CYP2C19 (0.44) | CYP2C19CYP1A2CYP2C9CHRM3CYP2D6 | |
| SCHEMBL9661051 | 0.79 | CYP2C9 (0.47) | CYP2C19CYP1A2CYP2C9TSHRCHRM3 | |
| SCHEMBL9317685 | 0.77 | TSHR (0.48) | CYP2C19CYP1A2CYP2C9TSHRCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585493-B1 | Catalyst compositions for the preparation of polymers of carbon monoxide with olefinically unsaturated compounds | SHELL INT RESEARCH (NL) | 1997-07-23 | — | — | EP | disclosed |
| US-5350725-A | Polymerization process | SHELL OIL COMPANY (US) | 1994-09-27 | — | — | US | disclosed |
| EP-0585493-A1 | Catalyst compositions for the preparation of polymers of carbon monoxide with olefinically unsaturated compounds | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1994-03-09 | — | — | EP | disclosed |
| US-5247065-A | Polymerization of CO/olefin with bidentate ligand having 2-hydroxy-2-alkyl-1,3-propylene bridging group | SHELL OIL COMPANY (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0226511-B1 | 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1989-08-02 | — | — | EP | disclosed |
| US-4774248-A | Methods of treating depression and depressive states using 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives | SOCIETE ANONYME DITE: LABORATOIRE L. LAFON (FR) | 1988-09-27 | — | — | US | disclosed |
| EP-0226511-A1 | 5-Phenyl-1,4,5,6-tetrahydropyrimidine derivatives, preparation process and medicinal use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1987-06-24 | — | — | EP | disclosed |