Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 10/20 | 0.59 |
| ▸ | IL1B | P01584 | 3/20 | 0.59 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12450466 | 0.84 | CASP1 (0.61) | CASP1IL1B | |
| SCHEMBL12450470 | 0.79 | CASP1 (0.61) | CASP1IL1BELANE | |
| SCHEMBL950212 | 0.79 | CASP1 (0.61) | CASP1IL1BELANE | |
| SCHEMBL646080 | 0.77 | CASP1 (0.71) | CASP1IL1BELANEMEN1KMT2A | |
| SCHEMBL951210 | 0.75 | CASP1 (0.73) | CASP1IL1BELANECTRC | |
| SCHEMBL12914456 | 0.75 | CASP1 (0.62) | CASP1IL1B | |
| SCHEMBL645752 | 0.75 | CASP1 (0.62) | CASP1IL1B | |
| SCHEMBL12450458 | 0.75 | CASP1 (0.71) | CASP1IL1BELANE | |
| SCHEMBL4459947 | 0.74 | CASP1 (1.00) | CASP1IL1BELANECTRC | |
| SCHEMBL12522163 | 0.74 | CASP1 (0.83) | CASP1IL1BELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784628-A1 | INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | Vertex Pharmaceuticals Incorporated (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1995035308-A1 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-12-28 | — | — | WO | disclosed |