SCHEMBL8764429 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	LMNA	P02545	1/20	0.41

▸	THRB	P10828	1/20	0.41

▸	CYP2C19	P33261	1/20	0.41

▸	CYP3A4	P08684	1/20	0.39

▸	CYP2D6	P10635	1/20	0.39

▸	OPRK1	P41145	1/20	0.39

▸	CA12	O43570	5/20	0.37

▸	CA1	P00915	5/20	0.37

▸	CA2	P00918	5/20	0.37

▸	CA9	Q16790	5/20	0.37

▸	KMT2A	Q03164	1/20	0.36

▸	TYMP	P19971	3/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8763271	0.92	LMNA (0.42)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL8764258	0.88	LMNA (0.45)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL8764451	0.86	KMT2A (0.43)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL8763244	0.83	LMNA (0.39)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL6131633	0.82	LMNA (0.47)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL8764264	0.82	LMNA (0.49)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL5310693	0.82	LMNA (0.41)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL5310701	0.82	LMNA (0.41)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL8359968	0.82	LMNA (0.46)	LMNATHRBCYP2C19CYP3A4CYP2D6
SCHEMBL5316178	0.82	LMNA (0.41)	LMNATHRBCYP2C19CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0544412-B1	Rhenium and technetium complexes containing a hypoxia-localizing moiety	BRACCO INT BV (NL)	1997-07-23	—	—	EP	claimed