Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8765083 | 0.98 | HRH3 (0.47) | HRH3FPR3FPR2SCN5AMAPT | |
| SCHEMBL9329964 | 0.95 | SCN5A (0.50) | HRH3FPR3FPR2SCN5AMAPT | |
| Hydrochloric Acid SCHEMBL9322363 | 0.93 | SCN5A (0.49) | HRH3FPR3FPR2SCN5AMAPT | |
| SCHEMBL13519642 | 0.85 | CARM1 (0.50) | HRH3FPR3FPR2SCN5ACARM1 | |
| SCHEMBL19728165 | 0.84 | SCN5A (0.47) | HRH3FPR3FPR2SCN5ACARM1 | |
| SCHEMBL29254420 | 0.82 | HRH3 (0.62) | HRH3SCN5AMAPTCARM1PRMT6 | |
| SCHEMBL441058 | 0.81 | HRH3 (0.61) | HRH3FPR3FPR2MAPTHRH1 | |
| SCHEMBL10775459 | 0.80 | FPR3 (0.40) | HRH3FPR3FPR2SCN5AMAPT | |
| SCHEMBL13160710 | 0.79 | HRH3 (0.54) | HRH3FPR3FPR2SCN5ACARM1 | |
| SCHEMBL9322157 | 0.79 | HRH3 (0.45) | HRH3FPR3FPR2SCN5AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420116-B1 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | EP | claimed |
| US-5217979-A | Substituted alkyl piperidines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | claimed |
| EP-0420116-A2 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-04-03 | — | — | EP | claimed |
| EP-0420116-B1 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | EP | disclosed |