Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876472 | 1.00 | PDE4B (0.39) | PDE4BCCR1FFAR4POLBACACB | |
| SCHEMBL683379 | 0.85 | PDE4B (0.39) | PDE4BCCR1FFAR4POLBPDE4D | |
| SCHEMBL876960 | 0.85 | PDE4B (0.39) | PDE4BCCR1FFAR4POLBPDE4D | |
| SCHEMBL682764 | 0.84 | PDE4B (0.41) | PDE4BFFAR4POLBPDE4DPDE4A | |
| SCHEMBL876548 | 0.84 | PDE4B (0.41) | PDE4BFFAR4POLBPDE4DPDE4A | |
| SCHEMBL877365 | 0.83 | PDE4B (0.48) | PDE4BFFAR4POLBPDE4DPDE4A | |
| SCHEMBL682607 | 0.83 | PDE4B (0.48) | PDE4BFFAR4POLBPDE4DPDE4A | |
| SCHEMBL682602 | 0.82 | PDE4B (0.39) | PDE4BCCR1FFAR4POLBPDE4D | |
| SCHEMBL2134799 | 0.82 | PDE4B (0.39) | PDE4BCCR1FFAR4POLBPDE4D | |
| SCHEMBL2140307 | 0.82 | PDE4B (0.39) | PDE4BCCR1FFAR4POLBPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |