Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 12/20 | 0.39 |
| ▸ | CTSA | P10619 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949375 | 1.00 | PDE2A (0.39) | PDE2ACTSASCN9AFPR2NR3C2 | |
| SCHEMBL8764720 | 0.81 | PDE2A (0.39) | PDE2ACTSA | |
| SCHEMBL949374 | 0.81 | PDE2A (0.39) | PDE2ACTSA | |
| SCHEMBL8764742 | 0.81 | PDE2A (0.38) | PDE2ANR3C2 | |
| SCHEMBL949377 | 0.81 | PDE2A (0.38) | PDE2ANR3C2 | |
| SCHEMBL951471 | 0.73 | DAO (0.45) | NR3C2 | |
| SCHEMBL949987 | 0.72 | DAO (0.41) | PDE2ANR3C2 | |
| SCHEMBL952739 | 0.69 | PDE2A (0.40) | PDE2A | |
| SCHEMBL27460339 | 0.68 | LTA4H (0.37) | — | |
| SCHEMBL27477560 | 0.65 | HSPA5 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784628-A1 | INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | Vertex Pharmaceuticals Incorporated (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1995035308-A1 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-12-28 | — | — | WO | disclosed |