Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466229 | 0.80 | PSMB5 (0.51) | SMN1; SMN2ALDH1A1KMT2AEPHX2CTSK | |
| SCHEMBL7895273 | 0.80 | PSMB5 (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7374853 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL7392610 | 0.72 | EPHX2 (0.71) | SMN1; SMN2ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL7895298 | 0.71 | PSMB5 (0.57) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7364710 | 0.71 | NPC1 (0.44) | ALDH1A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8516755 | 0.71 | SMN1; SMN2 (0.90) | SMN1; SMN2ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL7382806 | 0.70 | KDM4E (0.47) | SMN1; SMN2ALDH1A1KMT2AEPHX2HDAC3 | |
| SCHEMBL6357075 | 0.69 | SMN1; SMN2 (0.74) | SMN1; SMN2ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4260290 | 0.68 | KMT2A (0.59) | SMN1; SMN2ALDH1A1KMT2AMEN1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784629-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | Chiroscience Limited (GB) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996011209-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | CHIROSCIENCE LIMITED (GB) | 1996-04-18 | — | — | WO | disclosed |