SCHEMBL7364710

SCHEMBL7364710

CC(C)C[C@@H]([C]=O)NC(=O)C(S)CCCN1C(=O)c2ccccc2C1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.44
HDAC7 Q8WUI4 6/20 0.42
HDAC1 Q13547 5/20 0.42
MMP1 P03956 6/20 0.41
MMP9 P14780 6/20 0.41
MMP3 P08254 8/20 0.41
MMP2 P08253 5/20 0.41
MMP7 P09237 2/20 0.41
MMP14 P50281 2/20 0.41
ELANE P08246 1/20 0.40
MMP13 P45452 1/20 0.39
HDAC8 Q9BY41 3/20 0.39
HDAC3 O15379 2/20 0.39
HDAC4 P56524 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC10 Q969S8 2/20 0.39
HDAC11 Q96DB2 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
HDAC9 Q9UKV0 2/20 0.39
HDAC5 Q9UQL6 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6953525 0.83 MME (0.57) HDAC7HDAC1MMP1MMP9MMP3
SCHEMBL7364713 0.83 CAPN1 (0.44) NPC1HDAC7HDAC1MMP1MMP9
SCHEMBL8762966 0.81 MMP9 (0.44) NPC1MMP1MMP9MMP3MMP2
SCHEMBL6953223 0.79 MMP3 (0.63) MMP1MMP9MMP3MMP2MMP7
SCHEMBL7384875 0.78 MMP1 (0.58) MMP1MMP9MMP3MMP2MMP7
SCHEMBL7427129 0.78 MMP1 (0.58) MMP1MMP9MMP3MMP2MMP7
SCHEMBL7898741 0.78 MMP1 (0.58) MMP1MMP9MMP3MMP2MMP7
SCHEMBL6415164 0.78 MMP1 (0.58) MMP1MMP9MMP3MMP2MMP7
SCHEMBL7384525 0.78 MME (0.58) MMP1MMP9MMP3MMP2MMP7
SCHEMBL8387108 0.78 MME (0.58) MMP1MMP9MMP3MMP2MMP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1028716-A1 METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION WARNER-LAMBERT COMPANY (US) 2000-08-23 EP disclosed
WO-1998025597-A2 METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION WARNER-LAMBERT COMPANY (US) 1998-06-18 WO disclosed