Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.53 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8764581 | 0.96 | PTGS2 (0.49) | PTGS2MAPTNPC1ALDH1A1NFKB1 | |
| SCHEMBL8765432 | 0.95 | PTGS2 (0.47) | PTGS2PSDMAPTNPC1ALDH1A1 | |
| SCHEMBL8765507 | 0.91 | PTGS2 (0.43) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL8765554 | 0.89 | PTGS2 (0.55) | PTGS2PTGS1CA9 | |
| SCHEMBL8765351 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL8765305 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL8765262 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8766023 | 0.85 | PTGS2 (0.53) | PTGS2MAPTNPC1ALDH1A1NFKB1 | |
| SCHEMBL8765498 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8765491 | 0.85 | PTGS2 (0.47) | PTGS2MAPTNFKB1PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5401765-A | FOR TREATING ARTHRITIS, PAIN AND FEVER | Searle, G. D. (US) | 1995-03-28 | — | — | US | disclosed |