SCHEMBL8765732

SCHEMBL8765732

CC(N)Oc1cccc(O)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.53
CHRNB4 P30926 2/20 0.49
CHRNA3 P32297 2/20 0.49
ADRB1 P08588 1/20 0.47
MIF P14174 1/20 0.47
HTR2A P28223 1/20 0.47
ADRA1A P35348 1/20 0.47
HTR2B P41595 1/20 0.47
ESR1 P03372 2/20 0.44
ESR2 Q92731 2/20 0.44
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
LMNA P02545 2/20 0.42
HIF1A Q16665 1/20 0.42
KDM4E B2RXH2 1/20 0.42
CA12 O43570 2/20 0.42
ALDH1A1 P00352 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
CA14 Q9ULX7 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7651909 0.85 TAAR1 (0.44) CYP3A4HTR2AHTR2BKDM4EALDH1A1
SCHEMBL105731 0.83 CYP3A4 (0.62) CYP3A4CHRNB4CHRNA3ESR1ESR2
SCHEMBL8697795 0.83 CYP3A4 (0.57) CYP3A4CHRNB4CHRNA3ADRB1MIF
SCHEMBL16902843 0.83 CYP3A4 (0.57) CYP3A4CHRNB4CHRNA3ADRB1MIF
SCHEMBL30398332 0.83 CYP3A4 (0.62) CYP3A4CHRNB4CHRNA3ESR1ESR2
SCHEMBL31314901 0.82 CYP3A4 (0.55) CYP3A4CHRNB4CHRNA3ADRB1MIF
SCHEMBL2467241 0.82 CYP3A4 (0.55) CYP3A4CHRNB4CHRNA3ADRB1MIF
SCHEMBL23950173 0.80 CYP3A4 (0.53) CYP3A4CHRNB4CHRNA3ADRB1MIF
SCHEMBL9987948 0.78 CYP3A4 (0.52) CYP3A4CHRNB4CHRNA3ADRB1MIF
SCHEMBL10436347 0.78 CYP3A4 (0.61) CYP3A4CHRNB4CHRNA3ADRB1MIF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778267-A1 SULFONAMIDE DERIVATIVES AND INSECTICIDE, MITICIDE AND NEMATICIDE CONTAINING THE SAME OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1997-06-11 EP disclosed