Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.51 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765902 | 1.00 | AR (0.60) | ARKCNH2SRD5A2SRD5A1 | |
| SCHEMBL8539064 | 0.82 | SRD5A1 (0.68) | SRD5A2SRD5A1 | |
| SCHEMBL8539060 | 0.82 | SRD5A1 (0.68) | SRD5A2SRD5A1 | |
| SCHEMBL8538488 | 0.80 | AR (0.58) | ARKCNH2SRD5A2 | |
| SCHEMBL8538486 | 0.80 | AR (0.58) | ARKCNH2SRD5A2 | |
| SCHEMBL8498646 | 0.80 | AR (0.54) | ARKCNH2SRD5A2 | |
| SCHEMBL13403555 | 0.80 | AR (0.69) | ARKCNH2SRD5A2 | |
| SCHEMBL8077683 | 0.79 | AR (0.57) | ARKCNH2SRD5A2SRD5A1 | |
| SCHEMBL8077679 | 0.79 | AR (0.57) | ARKCNH2SRD5A2SRD5A1 | |
| SCHEMBL13403492 | 0.79 | AR (0.67) | ARKCNH2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646007-B1 | NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17$g(b)-SUBSTITUTED-4-AZA-5$g(a)-ANDROSTAN-3-ONES AS 5$g(a)-REDUCTASE INHIBITORS | MERCK & CO INC (US) | 1997-08-13 | — | — | EP | claimed |
| EP-0646007-A4 | — | — | 1995-04-26 | — | — | EP | claimed |
| EP-0646007-A1 | NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17-g(b)-SUBSTITUTED-4-AZA-5-g(a)-ANDROSTAN-3-ONES AS 5-g(a)-REDUCTASE INHIBITORS. | MERCK & CO INC (US) | 1995-04-05 | — | — | EP | claimed |
| WO-1993023050-A1 | NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | claimed |