Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | RARA | P10276 | 4/20 | 0.41 |
| ▸ | RARB | P10826 | 4/20 | 0.41 |
| ▸ | RARG | P13631 | 4/20 | 0.41 |
| ▸ | RXRA | P19793 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765307 | 0.96 | PTGS2 (0.46) | PDPK1RARARARBRARGRXRA | |
| SCHEMBL8764491 | 0.95 | PTGS2 (0.43) | PDPK1RARARARBRARGRXRA | |
| SCHEMBL8765507 | 0.92 | PTGS2 (0.43) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL8765163 | 0.90 | PDPK1 (0.55) | PDPK1PTGS2CYP2C9PTGS1 | |
| SCHEMBL8765305 | 0.87 | PTGS2 (0.51) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL8765262 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8765351 | 0.87 | PTGS2 (0.43) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL8765727 | 0.86 | PDPK1 (0.52) | PDPK1PTGS2CYP2C9PTGS1 | |
| SCHEMBL8765498 | 0.86 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8765079 | 0.86 | PTGS2 (0.48) | PTGS2CYP2C9PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0731794-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995015317-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |
| US-5401765-A | FOR TREATING ARTHRITIS, PAIN AND FEVER | Searle, G. D. (US) | 1995-03-28 | — | — | US | disclosed |