Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876199 | 0.87 | KDM4E (0.58) | KDM4EMAPTPTGER4POLBCYP1A2 | |
| SCHEMBL876555 | 0.86 | PTGER4 (0.68) | KDM4EMAPTPTGER4POLBPPARG | |
| SCHEMBL876663 | 0.84 | KDM4E (0.61) | KDM4EMAPTPTGER4POLBPPARG | |
| SCHEMBL876906 | 0.84 | KDM4E (0.64) | KDM4EMAPTPTGER4POLBCYP1A2 | |
| SCHEMBL881217 | 0.82 | PTGER4 (0.81) | PTGER4PTGER2 | |
| SCHEMBL876428 | 0.81 | KDM4E (0.72) | KDM4EMAPTPTGER4PPARGCYP1A2 | |
| SCHEMBL876593 | 0.81 | PTGER4 (0.60) | KDM4EMAPTPTGER4POLBCYP1A2 | |
| SCHEMBL26416648 | 0.80 | KDM4E (0.58) | KDM4EMAPTPTGER4CYP1A2CYP2C9 | |
| SCHEMBL15249979 | 0.78 | PTGER4 (0.70) | PTGER4PTGER2 | |
| SCHEMBL875886 | 0.78 | KDM4E (0.70) | KDM4EMAPTPTGER4POLBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619182-B1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MAN CO LTD (JP) | 2016-11-09 | — | — | EP | disclosed |
| EP-3061751-A1 | PHARMACEUTICAL COMPOSITION | Eisai R&D Management Co., Ltd. (JP) | 2016-08-31 | — | — | EP | disclosed |
| US-9000024-B2 | Pharmaceutical composition | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-07 | — | — | US | disclosed |
| US-20140155452-A1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-06-05 | — | — | US | disclosed |
| US-20130237578-A1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-12 | — | — | US | disclosed |
| EP-2619182-A1 | PHARMACEUTICAL COMPOSITION | Eisai R&D Management Co., Ltd. (JP) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012039972-A1 | PHARMACEUTICAL COMPOSITION | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155452-A1 | PHARMACEUTICAL COMPOSITION | CYP3A5, CYP2C19, CYP3A7 | KDM4E 3744/4885MAPT 1260/4885PTGER4 147/4885 |
| US-20130237578-A1 | PHARMACEUTICAL COMPOSITION | CYP3A5, CYP2C19, CYP3A7 | KDM4E 3744/4885MAPT 1260/4885PTGER4 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.