Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766162 | 0.92 | HMGCR (0.42) | HMGCRFDPSKMT2AMEN1NR1I2 | |
| SCHEMBL8766544 | 0.87 | FDPS (0.37) | HMGCRFDPSKMT2AMEN1NR1I2 | |
| SCHEMBL8766481 | 0.86 | FDPS (0.36) | HMGCRFDPSKMT2AMEN1NR1I2 | |
| SCHEMBL8766072 | 0.84 | HMGCR (0.44) | HMGCRFDPSKMT2AMEN1NR1I2 | |
| SCHEMBL8766645 | 0.84 | FDPS (0.41) | HMGCRFDPSKMT2AMEN1GAA | |
| SCHEMBL8766578 | 0.83 | HMGCR (0.44) | HMGCRKMT2AMEN1NR1I2GAA | |
| SCHEMBL8766494 | 0.81 | HMGCR (0.44) | HMGCRFDPSKMT2AMEN1NR1I2 | |
| SCHEMBL7119208 | 0.76 | HMGCR (0.43) | HMGCRFDPSKMT2AMEN1NR1I2 | |
| SCHEMBL8766155 | 0.75 | HMGCR (0.42) | HMGCRFDPSKMT2AMEN1NR1I2 | |
| SCHEMBL8766734 | 0.74 | ESRRG (0.41) | HMGCRKMT2AMEN1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559079-B1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR SA (CH) | 1997-08-13 | — | — | EP | claimed |
| EP-0559079-A1 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them | SYMPHAR S.A. (CH) | 1993-09-08 | — | — | EP | claimed |