Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9067719 | 0.74 | POLB (0.50) | POLBKMT2AL3MBTL1PKMPTPN1 | |
| SCHEMBL9350937 | 0.73 | KMT2A (0.38) | POLBKMT2AL3MBTL1PKMPTPN1 | |
| SCHEMBL9752072 | 0.73 | POLB (0.49) | POLBKMT2AL3MBTL1PKMPTPN1 | |
| SCHEMBL9752073 | 0.73 | POLB (0.49) | POLBKMT2AL3MBTL1PKMPTPN1 | |
| SCHEMBL8765884 | 0.72 | CYP2D6 (0.38) | ALDH1A1MAPTCYP2C19SMN1; SMN2CYP2D6 | |
| SCHEMBL28958739 | 0.72 | HCAR2 (0.41) | POLBKMT2AL3MBTL1PKMPTPN1 | |
| SCHEMBL8765585 | 0.72 | HPGD (0.48) | POLBKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL8766536 | 0.70 | TBXA2R (0.38) | MAPTSMN1; SMN2CYP2D6HDAC3MAPK1 | |
| SCHEMBL20394566 | 0.69 | POLB (0.47) | POLBKMT2AL3MBTL1PKMPTPN1 | |
| SCHEMBL10405511 | 0.68 | POLB (0.42) | POLBKMT2AL3MBTL1PKMPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785782-A1 | DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY | Allergan (US) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011686-A1 | DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY | ALLERGAN (US) | 1996-04-25 | — | — | WO | disclosed |