SCHEMBL8766536

SCHEMBL8766536

C#CC(CCCC(=O)O)c1cccnn1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 2/20 0.38
TBXAS1 P24557 10/20 0.37
CYP1A2 P05177 1/20 0.35
KMO O15229 1/20 0.35
CES1 P23141 1/20 0.35
P2RX7 Q99572 1/20 0.33
HDAC3 O15379 1/20 0.33
MAPK1 P28482 1/20 0.33
ADRA1A P35348 1/20 0.33
HDAC4 P56524 1/20 0.33
SLC6A3 Q01959 1/20 0.33
HDAC1 Q13547 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8765884 0.75 CYP2D6 (0.38) TBXA2RTBXAS1CYP1A2HDAC3MAPK1
SCHEMBL8766799 0.73 TBXAS1 (0.38) TBXA2RTBXAS1CYP2D6NFKB1LMNA
SCHEMBL8766512 0.71 CYP1A2 (0.41) CYP1A2CES1P2RX7HDAC4SLC6A9
SCHEMBL8766712 0.70 POLB (0.41) CYP1A2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL8765585 0.69 HPGD (0.48) TBXAS1CYP1A2CES1HDAC3MAPK1
SCHEMBL27654405 0.68 TBXA2R (0.47) TBXA2RTBXAS1CYP1A2CES1P2RX7
SCHEMBL6046250 0.66 CYP1A2 (0.50) TBXA2RTBXAS1CYP1A2CES1HDAC3
Adipic Acid SCHEMBL26662205 0.66 TBXA2R (0.48) TBXA2RTBXAS1CYP1A2CES1P2RX7
Adipic Acid SCHEMBL26662210 0.66 TBXA2R (0.48) TBXA2RTBXAS1CYP1A2CES1P2RX7
SCHEMBL27449978 0.65 TBXAS1 (0.53) TBXA2RTBXAS1CYP1A2CES1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785782-A1 DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY Allergan (US) 1997-07-30 EP disclosed
WO-1996011686-A1 DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY ALLERGAN (US) 1996-04-25 WO disclosed