Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823060 | 0.78 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8766828 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7440974 | 0.75 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3375194 | 0.72 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7444972 | 0.72 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8766261 | 0.72 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6919617 | 0.72 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7364691 | 0.72 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7696540 | 0.72 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6817584 | 0.71 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629197-B1 | 1-ALKOXY-(2-ALKOXY- OR CYCLOALKOXY)-4-(CYCLO THIOALKYL- OR CYCLOTHIOALKENYL)BENZENES AS INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASE AND TUMOUR NECROSIS FACTOR | RHONE POULENC RORER LTD (GB) | 1997-08-20 | — | — | EP | claimed |