SCHEMBL8767158

SCHEMBL8767158

FC(F)(F)Oc1ccc(-c2ccc(C3CCC(C4CCCC4)CC3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.44
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
S1PR1 P21453 1/20 0.41
GRIN2B Q13224 1/20 0.40
GABBR2 O75899 1/20 0.39
GABBR1 Q9UBS5 1/20 0.39
SCN10A Q9Y5Y9 1/20 0.39
EPHX2 P34913 2/20 0.39
EPHX1 P07099 1/20 0.39
P2RY14 Q15391 1/20 0.38
KIF11 P52732 1/20 0.38
NISCH Q9Y2I1 1/20 0.38
GALR1 P47211 1/20 0.38
KDM1A O60341 1/20 0.38
RCOR1 Q9UKL0 1/20 0.38
HRH3 Q9Y5N1 1/20 0.36
TRPV1 Q8NER1 1/20 0.36
GCGR P47871 1/20 0.36
GIPR P48546 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8767160 1.00 L3MBTL1 (0.44) L3MBTL1MEN1KMT2AS1PR1GRIN2B
SCHEMBL8767731 0.95 MEN1 (0.44) L3MBTL1MEN1KMT2AS1PR1GRIN2B
SCHEMBL18392454 0.94 EPHX2 (0.43) L3MBTL1MEN1KMT2AS1PR1EPHX2
SCHEMBL18392609 0.89 S1PR1 (0.49) L3MBTL1MEN1KMT2AS1PR1GRIN2B
SCHEMBL8767334 0.88 MEN1 (0.40) L3MBTL1MEN1KMT2AEPHX2EPHX1
SCHEMBL8767326 0.88 MEN1 (0.40) L3MBTL1MEN1KMT2AEPHX2EPHX1
SCHEMBL8767322 0.88 MEN1 (0.40) L3MBTL1MEN1KMT2AEPHX2EPHX1
SCHEMBL8768459 0.85 ESR2 (0.42) L3MBTL1MEN1KMT2AEPHX2EPHX1
SCHEMBL4564168 0.85 L3MBTL1 (0.47) L3MBTL1MEN1KMT2AGRIN2BEPHX2
SCHEMBL8767205 0.84 CYP3A4 (0.42) L3MBTL1MEN1KMT2AS1PR1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789067-A1 Cyclopentyl derivatives useful as liquid crystals Rolic AG (CH) 1997-08-13 EP disclosed