Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9337705 | 0.87 | NPC1 (0.77) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL3199140 | 0.87 | TP53 (0.64) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL19049114 | 0.83 | NPC1 (0.67) | NPC1RAB9APAX8JAK2TP53 | |
| Hydrochloric Acid SCHEMBL7361904 | 0.83 | NPC1 (0.50) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL29266757 | 0.83 | NPC1 (0.75) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL8621458 | 0.83 | NPC1 (0.66) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL4167170 | 0.82 | TP53 (0.57) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL1115056 | 0.81 | ALDH1A1 (0.58) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL1114803 | 0.81 | ALDH1A1 (0.58) | NPC1RAB9APAX8JAK2TP53 | |
| SCHEMBL13811408 | 0.81 | TP53 (0.56) | NPC1RAB9APAX8JAK2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781268-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |