⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL8235 | 0.97 | — | — | |
| Uracil SCHEMBL3798527 | 0.97 | CRBN (1.00) | — | |
| Uracil SCHEMBL5089507 | 0.97 | — | — | |
| Uracil SCHEMBL18010636 | 0.94 | — | — | |
| Uracil SCHEMBL2557975 | 0.94 | — | — | |
| Uracil SCHEMBL11130705 | 0.94 | — | — | |
| Uracil SCHEMBL16116311 | 0.94 | — | — | |
| Uracil SCHEMBL4664232 | 0.94 | CRBN (0.94) | — | |
| Uracil SCHEMBL21385227 | 0.94 | — | — | |
| Uracil SCHEMBL2161716 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116656795-A | Nucleotide derivatives and methods of use thereof | 纽约哥伦比亚大学董事会 | 2023-08-29 | — | — | CN | disclosed |
| CN-109661232-B | Nucleotide derivatives and methods of use thereof | 纽约哥伦比亚大学董事会 | 2023-03-03 | — | — | CN | disclosed |
| CN-114989235-A | Design and synthesis of nucleotides based on novel disulfide linkers for use as reversible terminators for DNA sequencing by synthesis | 哥伦比亚大学董事会 | 2022-09-02 | — | — | CN | disclosed |
| CN-108779138-B | Design and synthesis of nucleotides based on novel disulfide linkers for use as reversible terminators for DNA sequencing by synthesis | 哥伦比亚大学董事会 | 2022-06-17 | — | — | CN | disclosed |
| CN-112823011-A | Gene targets for T cell-based immunotherapy | 加利福尼亚大学董事会 | 2021-05-18 | — | — | CN | disclosed |
| CN-110366680-A | Apparatus and method for continuous diagnosis of macromolecules | 阿克斯比尔公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-110330552-A | The synthetic method of acetic acid Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(Hor)-D-4Aph(Cbm)-Leu-Lys(iPr)-Pro-D-Ala-NH2 | 凯莱英生命科学技术(天津)有限公司 | 2019-10-15 | — | — | CN | disclosed |
| CN-109790211-A | Anti-KRAS-G12D T cell receptor | 美国卫生和人力服务部 | 2019-05-21 | — | — | CN | disclosed |
| CN-109563514-A | Highly specific genome editing using chemically modified guide RNAs | 安捷伦科技有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109069508-A | EZH2 inhibitor and application thereof | 达纳-法伯癌症研究所股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-1658899-B | Modified CEA nucleic acids and expression vectors | AVENTIS PASTEUR | 2013-01-02 | — | — | CN | disclosed |
| CN-1813187-A | Nucleic acid encoding a g-protein-coupled receptor, and uses thereof | AVENTIS PHARMA INC (US) | 2006-08-02 | — | — | CN | disclosed |
| CN-1658899-A | Modified CEA nucleic acids and expression vectors | AVENTIS PASTEUR (CA) | 2005-08-24 | — | — | CN | disclosed |
| EP-0592511-B1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS | ANTIVIRALS INC (US) | 1997-08-20 | — | — | EP | disclosed |
| EP-0669927-A1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS | ANTIVIRALS INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5405938-A | Hydrogen bonding an N-heterocyclic-substituted ribose-based polymer to a double-stranded DNA to block genetic activity, to diagnose for pathogens and to aid in genetic engineering | ANTI-GENE DEVELOPMENT GROUP (US) | 1995-04-11 | — | — | US | disclosed |
| WO-1994012517-A1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS | ANTIVIRALS INC. (US) | 1994-06-09 | — | — | WO | disclosed |
| EP-0592511-A1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS. | ANTIVIRALS INC (US) | 1994-04-20 | — | — | EP | disclosed |
| WO-1993000352-A1 | SEQUENCE-SPECIFIC BINDING POLYMERS FOR DUPLEX NUCLEIC ACIDS | ANTIVIRALS INC. (US) | 1993-01-07 | — | — | WO | disclosed |
| US-5166315-A | Polynucleotides for genetic engineering | ANTI-GENE DEVELOPMENT GROUP (US) | 1992-11-24 | — | — | US | disclosed |