Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.59 |
| ▸ | PPARG | P37231 | 5/20 | 0.59 |
| ▸ | PPARD | Q03181 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767784 | 0.99 | PPARA (0.61) | PPARAPPARGPPARDHDAC1HDAC6 | |
| SCHEMBL8768686 | 0.99 | PPARA (0.61) | PPARAPPARGPPARDHDAC1HDAC6 | |
| SCHEMBL8767727 | 0.99 | PPARA (0.61) | PPARAPPARGPPARDHDAC1HDAC6 | |
| SCHEMBL8924339 | 0.93 | GAA (0.52) | PPARAPPARGPPARDHDAC1HDAC6 | |
| SCHEMBL8926283 | 0.92 | PPARA (0.68) | PPARAPPARGPPARDMAPT | |
| SCHEMBL8767844 | 0.91 | PPARA (0.58) | PPARAPPARGPPARDHDAC1HDAC6 | |
| SCHEMBL6941878 | 0.91 | PPARA (0.72) | PPARAPPARGPPARD | |
| SCHEMBL8768980 | 0.89 | PPARA (0.50) | PPARAPPARGPPARDHDAC1HDAC6 | |
| SCHEMBL8768112 | 0.89 | PPARA (0.56) | PPARAPPARGPPARDHDAC1HDAC6 | |
| SCHEMBL8767827 | 0.89 | GAA (0.52) | PPARAPPARGPPARDGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0639178-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS. | WELLCOME FOUND (GB) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992010468-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-25 | — | — | WO | disclosed |