Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767743 | 0.91 | HDAC1 (0.49) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL8767733 | 0.91 | LMNA (0.49) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL8767804 | 0.89 | HDAC1 (0.49) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL8768644 | 0.87 | HDAC1 (0.49) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL9577853 | 0.85 | TSHR (0.56) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL8768948 | 0.85 | HDAC1 (0.49) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL9255344 | 0.84 | HDAC1 (0.48) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL8767791 | 0.84 | TSHR (0.50) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL9577605 | 0.84 | TSHR (0.51) | HDAC1HDAC6GAAHTTTSHR | |
| SCHEMBL8767687 | 0.83 | TSHR (0.51) | HDAC1HDAC6GAAHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |