Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.44 |
| ▸ | RHOC | P08134 | 6/20 | 0.43 |
| ▸ | RHOA | P61586 | 6/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CLPP | Q16740 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8503520 | 0.98 | GAA (0.57) | GAACES2HDAC3HDAC8HDAC6 | |
| SCHEMBL8768136 | 0.90 | GAA (0.49) | GAACES2HDAC3HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL8504149 | 0.89 | GAA (0.48) | GAACES2HDAC3HDAC8HDAC6 | |
| SCHEMBL8768316 | 0.89 | GAA (0.48) | GAACES2HDAC3HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL8742165 | 0.89 | GAA (0.48) | GAACES2HDAC3HDAC8HDAC6 | |
| SCHEMBL8170159 | 0.89 | GAA (0.48) | GAACES2HDAC3HDAC6RHOC | |
| Hydrochloric Acid SCHEMBL8503854 | 0.88 | GAA (0.47) | GAACES2HDAC3HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL8506637 | 0.88 | GAA (0.47) | GAACES2HDAC3HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL8506916 | 0.88 | GAA (0.47) | GAAHDAC3HDAC6RHOCRHOA | |
| Hydrochloric Acid SCHEMBL9043440 | 0.85 | GAA (0.44) | GAACES2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |