Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | VNN1 | O95497 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | RHOC | P08134 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8504149 | 0.98 | GAA (0.48) | GAAVNN1CES2DDR1HDAC3 | |
| SCHEMBL8767967 | 0.90 | GAA (0.58) | GAACES2HDAC3HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL8503520 | 0.89 | GAA (0.57) | GAACES2HDAC3HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL8503844 | 0.83 | CES2 (0.45) | CES2HDAC3HDAC6HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL8742165 | 0.83 | GAA (0.48) | GAACES2HDAC3HDAC6HDAC1 | |
| SCHEMBL8170159 | 0.83 | GAA (0.48) | GAACES2DDR1HDAC3HDAC6 | |
| SCHEMBL8768316 | 0.83 | GAA (0.48) | GAACES2HDAC3HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL8506637 | 0.82 | GAA (0.47) | GAACES2HDAC3HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL8503854 | 0.82 | GAA (0.47) | GAACES2HDAC3HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL8506916 | 0.82 | GAA (0.47) | GAADDR1HDAC3HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | claimed |