SCHEMBL8768958

SCHEMBL8768958

COc1ccc(CCNc2c(Nc3ccc(C#N)cc3)c(=O)c2=O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 3/20 0.52
FES P07332 1/20 0.52
FGFR1 P11362 1/20 0.52
FLT4 P35916 1/20 0.52
MAPT P10636 4/20 0.51
POLB P06746 3/20 0.51
HDAC3 O15379 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC2 Q92769 1/20 0.51
HDAC10 Q969S8 1/20 0.51
HDAC11 Q96DB2 1/20 0.51
HDAC8 Q9BY41 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51
HDAC5 Q9UQL6 1/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
GSK3B P49841 2/20 0.44
ROCK2 O75116 1/20 0.44
GSK3A P49840 1/20 0.44
ROCK1 Q13464 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8768613 0.86 GSK3B (0.50) KDRFESFGFR1FLT4MAPT
SCHEMBL30672992 0.85 FPR2 (0.55) KDRFESFGFR1FLT4MAPT
SCHEMBL8767677 0.80 KCNH2 (0.54) KDRFESFGFR1FLT4MAPT
SCHEMBL8872677 0.76 MAPKAPK2 (0.48) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL8872684 0.76 MAPKAPK2 (0.48) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL8371911 0.75 ABCB1 (0.50) HDAC3HDAC1HDAC2HDAC10HDAC11
SCHEMBL5450744 0.75 GAA (0.68) KDRMAPTPOLBMEN1KMT2A
SCHEMBL20053881 0.75 MAOB (0.65) MAPTPOLBMAOAMAOBVNN1
SCHEMBL30673020 0.75 CNR1 (0.46) KDRFESFGFR1FLT4HDAC3
SCHEMBL11470006 0.74 MAPT (0.54) KDRMAPTPOLBMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed