Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.61 |
| ▸ | STK3 | Q13188 | 2/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.61 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.61 |
| ▸ | PRKCG | P05129 | 1/20 | 0.61 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | AKT1 | P31749 | 1/20 | 0.61 |
| ▸ | AKT2 | P31751 | 1/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.61 |
| ▸ | PRKCI | P41743 | 1/20 | 0.61 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877133 | 0.92 | PRKD3 (0.59) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL877014 | 0.90 | PRKD3 (0.51) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL877965 | 0.90 | ROCK2 (0.59) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL877549 | 0.87 | PRKD3 (0.54) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL19962178 | 0.86 | PRKD3 (0.68) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL882819 | 0.86 | PRKD3 (0.74) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL882711 | 0.84 | ROCK2 (0.74) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL16882611 | 0.84 | PRKD3 (0.88) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL1723113 | 0.83 | ROCK2 (0.53) | PRKD3METROCK2CSNK2A1STK3 | |
| SCHEMBL877820 | 0.82 | ROCK2 (0.54) | PRKD3METROCK2CSNK2A1STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040499-A2 | METABOLIC INHIBITORS | SURFACE LOGIX, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| EP-1865958-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105081-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-10-05 | — | — | WO | disclosed |