Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770653 | 1.00 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL8770227 | 0.88 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL8770638 | 0.88 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL8359480 | 0.85 | ALDH1A1 (0.49) | NPC1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL8770183 | 0.83 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL8770323 | 0.83 | KMT2A (0.52) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL8770181 | 0.83 | KMT2A (0.52) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL8770197 | 0.83 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL8770242 | 0.78 | EPHX2 (0.51) | NPC1RAB9APOLBALDH1A1CYP1A2 | |
| SCHEMBL8770302 | 0.77 | F2 (0.49) | NPC1RAB9APOLBALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632020-B1 | Allophanic acid derivatives | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5494922-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-02-27 | — | — | US | disclosed |
| US-5463011-A | Allophanic acid derivatives from reacting amines with isocyanate components; anticoagulants; inhibits binding of fibrinogen to glycoprotein IIa/IIIb | ZENECA LIMITED (GB) | 1995-10-31 | — | — | US | disclosed |
| EP-0632020-A1 | Allophanic acid derivatives | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |