SCHEMBL8771780

SCHEMBL8771780

CC(C)[C@H](N)C(=O)N(C(=O)OCCCl)C(C)COc1ccc(C#N)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 7/20 0.45
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA4 P43681 1/20 0.42
MMP3 P08254 3/20 0.41
ALDH1A1 P00352 3/20 0.40
HPGD P15428 1/20 0.40
MAPT P10636 1/20 0.38
MAOB P27338 1/20 0.37
ADRB2 P07550 1/20 0.33
ADRB1 P08588 1/20 0.33
ADRB3 P13945 1/20 0.33
KDM1A O60341 1/20 0.33
MMP1 P03956 1/20 0.33
MMP9 P14780 1/20 0.33
MMP13 P45452 1/20 0.33
ABCB11 O95342 1/20 0.33
KCNH2 Q12809 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8772017 0.83 MMP2 (0.46) MMP2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8772004 0.81 MMP2 (0.45) MMP2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8771806 0.78 MMP2 (0.41) MMP2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8771913 0.74 MMP2 (0.46) MMP2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8771761 0.74 MMP2 (0.44) MMP2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8771989 0.70 MMP2 (0.45) MMP2CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL8771764 0.69 MMP2 (0.54) MMP2MMP3ALDH1A1MAPT
SCHEMBL8771775 0.68 MMP2 (0.46) MMP2MMP3ALDH1A1HPGDMAPT
Hydrochloric Acid SCHEMBL8771788 0.68 MMP2 (0.53) MMP2MMP3ALDH1A1MAPT
SCHEMBL8771972 0.67 MAPT (0.47) ALDH1A1MAPTMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648740-B1 AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS KUMIAI CHEMICAL INDUSTRY CO (JP) 1997-10-08 EP disclosed