Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12987491 | 0.80 | KDM1A (0.46) | GRM2CYP2C9KMOCYP11B1 | |
| SCHEMBL12970151 | 0.74 | KDM1A (0.53) | GRM2 | |
| SCHEMBL12987241 | 0.73 | AMY1A (0.50) | GRM2CYP2C9CYP11B1CYP11B2 | |
| SCHEMBL875492 | 0.72 | GRM4 (0.45) | PTGDR2CYP4F2CYP4A11 | |
| SCHEMBL8613864 | 0.72 | MEN1 (0.46) | GRM2CYP2C9ALOX5APFEN1 | |
| SCHEMBL16675768 | 0.72 | FYN (0.55) | CYP2C9 | |
| SCHEMBL15115340 | 0.72 | RECQL (0.37) | PTGDR2RECQLCYP4F2CYP4A11 | |
| SCHEMBL9327112 | 0.71 | CYP11B1 (0.46) | GRM2CYP2C9CYP11B1CYP11B2ALOX5AP | |
| SCHEMBL31152600 | 0.71 | KDM1A (0.48) | CYP11B1CYP11B2ALOX5APFEN1 | |
| SCHEMBL875959 | 0.71 | CYP4F2 (0.46) | PTGDR2RECQLS1PR3CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619203-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | Glaxo Group Limited (GB) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012037782-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | GLAXO GROUP LIMITED (GB) | 2012-03-29 | — | — | WO | disclosed |