Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 6/20 | 0.64 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.43 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891845 | 1.00 | LTB4R (0.64) | LTB4RPLA2G4BPTGIRKMT2APTGER4 | |
| SCHEMBL8891001 | 0.90 | LTB4R (0.52) | LTB4RPTGIR | |
| SCHEMBL8890993 | 0.90 | LTB4R (0.52) | LTB4RPTGIR | |
| SCHEMBL8772225 | 0.81 | LTB4R (0.69) | LTB4RPTGER4 | |
| SCHEMBL8772212 | 0.81 | LTB4R (0.69) | LTB4RPTGER4 | |
| SCHEMBL8772230 | 0.81 | LTB4R (0.69) | LTB4RPTGER4 | |
| SCHEMBL8891515 | 0.79 | LTB4R (0.54) | LTB4RPTGIR | |
| SCHEMBL8772181 | 0.79 | LTB4R (0.54) | LTB4RPTGIR | |
| SCHEMBL8772149 | 0.79 | LTB4R (0.73) | LTB4RPTGER4 | |
| SCHEMBL8772164 | 0.79 | LTB4R (0.73) | LTB4RPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801061-A2 | Leucotrien-B4 derivatives, process for their preparation and their use as medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5614634-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5440044-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| EP-0477311-A1 | NEW LEUCOTRIENE B 4? DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-04-01 | — | — | EP | disclosed |
| WO-1991014676-A1 | NEW LEUCOTRIENE B4 DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-10-03 | — | — | WO | disclosed |