Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11875194 | 0.71 | MDM2 (0.50) | EPHX1MDM2PPARGPPARASMN1; SMN2 | |
| SCHEMBL11866750 | 0.68 | MDM2 (0.50) | EPHX1MDM2PPARGPPARASMN1; SMN2 | |
| SCHEMBL11177590 | 0.68 | PPARG (0.50) | EPHX1MDM2PPARGPPARASMN1; SMN2 | |
| SCHEMBL11769885 | 0.68 | PPARG (0.54) | EPHX1MDM2PPARGPPARASMN1; SMN2 | |
| SCHEMBL11279773 | 0.67 | KCNA5 (0.40) | SMN1; SMN2L3MBTL1LMNAKMT2AALDH1A1 | |
| SCHEMBL8373994 | 0.66 | CRBN (0.51) | CRBNDDB1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL11768677 | 0.66 | MDM2 (0.47) | EPHX1MDM2PPARGPPARASMN1; SMN2 | |
| SCHEMBL8773531 | 0.65 | BRD4 (0.36) | SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL27767630 | 0.65 | MDM2 (0.46) | EPHX1MDM2PPARGPPARASMN1; SMN2 | |
| SCHEMBL4779996 | 0.62 | MAPT (0.46) | EPHX1CRBNDDB1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |