Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443006 | 0.92 | POLB (0.41) | LMNAALDH1A1NPC1POLB | |
| SCHEMBL8443150 | 0.92 | KMT2A (0.45) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL8442084 | 0.92 | TRPV1 (0.48) | LMNAASAH1ALDH1A1KMT2A | |
| SCHEMBL27493521 | 0.92 | TRPV1 (0.48) | LMNAASAH1ALDH1A1KMT2A | |
| SCHEMBL27515042 | 0.92 | TRPV1 (0.48) | LMNAASAH1ALDH1A1KMT2A | |
| SCHEMBL8772503 | 0.92 | TRPV1 (0.48) | LMNAASAH1ALDH1A1KMT2A | |
| SCHEMBL27495125 | 0.92 | TRPV1 (0.48) | LMNAASAH1ALDH1A1KMT2A | |
| SCHEMBL8438732 | 0.92 | TRPV1 (0.48) | LMNAASAH1ALDH1A1KMT2A | |
| SCHEMBL27515045 | 0.92 | TRPV1 (0.48) | LMNAASAH1ALDH1A1KMT2A | |
| SCHEMBL8772522 | 0.91 | TRPV1 (0.46) | LMNAASAH1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |