Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27493521 | 1.00 | TRPV1 (0.48) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL27515042 | 1.00 | TRPV1 (0.48) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL8438732 | 1.00 | TRPV1 (0.48) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL27495125 | 1.00 | TRPV1 (0.48) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL27515045 | 1.00 | TRPV1 (0.48) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL8442084 | 1.00 | TRPV1 (0.48) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL8772522 | 0.99 | TRPV1 (0.46) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL8772515 | 0.95 | TRPV1 (0.53) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL8550924 | 0.94 | TRPV1 (0.43) | TRPV1EPHX2LMNATSHRGAA | |
| SCHEMBL20971533 | 0.94 | PLAAT3 (0.47) | TRPV1EPHX2LMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | disclosed |