Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771232 | 0.88 | ELANE (0.46) | RAB9AALDH1A1ELANESTSL3MBTL1 | |
| SCHEMBL27546795 | 0.88 | ELANE (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1ELANE | |
| SCHEMBL8419572 | 0.86 | ELANE (0.41) | SMN1; SMN2ALDH1A1ELANEL3MBTL1MAPK1 | |
| SCHEMBL14421954 | 0.85 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9AALDH1A1STS | |
| SCHEMBL7510046 | 0.84 | PTPN1 (0.44) | SMN1; SMN2ALDH1A1ELANESTSCA12 | |
| SCHEMBL227343 | 0.81 | RAB9A (0.50) | SMN1; SMN2NPC1RAB9AALDH1A1STS | |
| SCHEMBL8418566 | 0.81 | FDFT1 (0.45) | SMN1; SMN2ALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL9082761 | 0.81 | KDM4E (0.41) | SMN1; SMN2ALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL4979174 | 0.80 | HSD17B2 (0.57) | SMN1; SMN2NPC1RAB9AALDH1A1ELANE | |
| SCHEMBL24197027 | 0.80 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0654032-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1997-10-15 | — | — | EP | disclosed |
| EP-0654032-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS. | ZENECA LTD (GB) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003451-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |