SCHEMBL8772648

SCHEMBL8772648

CCc1cc(C(=O)CBr)ccc1O

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.57
HSP90AB1 P08238 1/20 0.57
HSD17B1 P14061 1/20 0.53
PTPN1 P18031 5/20 0.52
HTT P42858 2/20 0.51
ALDH1A1 P00352 1/20 0.51
HPGD P15428 1/20 0.51
GSK3B P49841 6/20 0.50
POLB P06746 1/20 0.50
PKM P14618 1/20 0.49
GNG2 P59768 1/20 0.48
GNB1 P62873 1/20 0.48
ESR1 P03372 2/20 0.46
ESR2 Q92731 2/20 0.46
JAK2 O60674 1/20 0.45
BACE1 P56817 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4344454 0.88 HTT (0.48) HSP90AA1HSP90AB1HSD17B1PTPN1HTT
SCHEMBL469649 0.85 PKM (0.62) HSP90AA1HSP90AB1PTPN1HTTALDH1A1
SCHEMBL30017193 0.85 PKM (0.62) HSP90AA1HSP90AB1PTPN1HTTALDH1A1
SCHEMBL2856590 0.85 HTT (0.68) HSP90AA1HSP90AB1HSD17B1PTPN1HTT
SCHEMBL6756073 0.83 HSP90AA1 (0.64) HSP90AA1HSP90AB1HSD17B1PTPN1HTT
SCHEMBL10462920 0.83 PTPN1 (0.50) HSP90AA1HSP90AB1PTPN1HTTALDH1A1
SCHEMBL10477831 0.82 PTPN1 (0.48) HSP90AA1HSP90AB1PTPN1HTTALDH1A1
SCHEMBL2054475 0.81 GSK3B (0.55) HSP90AA1HSP90AB1PTPN1HTTALDH1A1
SCHEMBL8647422 0.81 GSK3B (0.50) HSP90AA1HSP90AB1PTPN1HTTALDH1A1
SCHEMBL5465657 0.81 HSP90AA1 (0.57) HSP90AA1HSP90AB1HSD17B1PTPN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691349-A ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS ZENECA LIMITED (GB) 1997-11-25 US disclosed
EP-0654032-B1 QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS ZENECA LTD (GB) 1997-10-15 EP disclosed
EP-0654032-A1 QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS. ZENECA LTD (GB) 1995-05-24 EP disclosed
WO-1994003451-A1 QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS ZENECA LIMITED (GB) 1994-02-17 WO disclosed