Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | CASP1 | P29466 | 1/20 | 0.74 |
| ▸ | CASP7 | P55210 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | CRHBP | P24387 | 1/20 | 0.64 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | FABP3 | P05413 | 1/20 | 0.62 |
| ▸ | FABP4 | P15090 | 1/20 | 0.62 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037511 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL15281766 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL6581512 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL27568575 | 0.81 | PTGDR2 (0.69) | KDM4EALDH1A1PTGDR2 | |
| SCHEMBL16559078 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL13273561 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL18456826 | 0.79 | ALDH1A1 (0.65) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL18456829 | 0.79 | ALDH1A1 (0.65) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL18457140 | 0.79 | CA1 (0.67) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL1056164 | 0.78 | HDAC6 (1.00) | KDM4EALDH1A1KMT2AMEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115624549-A | Compositions and methods for treating muscular dystrophy using thromboxane-A2 receptor antagonists | 坎伯兰医药品股份有限公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-109152767-B | Compositions and methods for treating muscular dystrophy using thromboxane-A2 receptor antagonists | 坎伯兰医药品股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| US-20220211674-A1 | Thromboxane Receptor Antagonists in AERD/Asthma | CUMBERLAND PHARMACEUTICALS INC. (US) | 2022-07-07 | — | — | US | disclosed |
| CN-114569608-A | Thromboxane receptor antagonists in AERD/asthma | 坎伯兰医药品股份有限公司 | 2022-06-03 | — | — | CN | disclosed |
| WO-2022045074-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OBESITY | 国立大学法人東京大学 | 2022-03-03 | — | — | WO | disclosed |
| EP-2781508-B9 | NITROGEN-CONTAINING FUSED RING COMPOUNDS FOR USE AS CRTH2 ANTAGONISTS | KBP BIOSCIENCES CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |
| EP-0791360-A2 | Treatment of septic shock with anti-TNF antibodies | Bayer Corporation (US) | 1997-08-27 | — | — | EP | disclosed |