Phosphoric Acid

Phosphoric Acid

SCHEMBL8773417

CC(=O)O[C@H]1O[C@@H](C)[C@@H](O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.O=P(O)(O)O

nearest known ligand 0.42

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
OGA O60502 1/20 0.42
CYP3A4 P08684 6/20 0.39
CA9 Q16790 2/20 0.35
CA2 P00918 2/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
USP2 O75604 1/20 0.34
CYP2D6 P10635 2/20 0.33
THRB P10828 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RPS6KA3 P51812 1/20 0.32
RPS6KA1 Q15418 1/20 0.32
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15451493 0.93 OGA (0.46) OGACYP3A4CA9CA2CA12
SCHEMBL1686171 0.93 OGA (0.46) OGACYP3A4CA9CA2CA12
SCHEMBL16743504 0.93 OGA (0.46) OGACYP3A4CA9CA2CA12
SCHEMBL7538718 0.93 OGA (0.46) OGACYP3A4CA9CA2CA12
SCHEMBL18239034 0.88 OGA (0.44) OGACYP3A4CA9CA2CA12
SCHEMBL18082004 0.88 OGA (0.44) OGACYP3A4CA9CA2CA12
SCHEMBL13341455 0.88 OGA (0.44) OGACYP3A4CA9CA2CA12
SCHEMBL16508656 0.88 OGA (0.44) OGACYP3A4CA9CA2CA12
SCHEMBL15730189 0.82 OGA (0.42) OGACYP3A4CA9CA2CA12
SCHEMBL16315909 0.82 OGA (0.42) OGACYP3A4CA9CA2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801684-A1 PROCESS FOR THE COMPLETE REMOVAL OF PROTECTIVE GROUPS ON NUCLEOSIDE DIPHOSPHATE AND TRIPHOSPHATE SUGARS Novartis AG (CH) 1997-10-22 EP disclosed
WO-1996024683-A1 PROCESS FOR THE COMPLETE REMOVAL OF PROTECTIVE GROUPS ON NUCLEOSIDE DIPHOSPHATE AND TRIPHOSPHATE SUGARS NOVARTIS AG (CH) 1996-08-15 WO disclosed