Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28061158 | 0.97 | SMN1; SMN2 (0.46) | SMN1; SMN2GLAHSD17B10CA12CA1 | |
| Acetic Acid SCHEMBL5163643 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2GLAHSD17B10CA12CA1 | |
| Hydrogen Peroxide SCHEMBL11793831 | 0.91 | — | — | |
| SCHEMBL9400650 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2GLAHSD17B10CA12CA1 | |
| SCHEMBL7093958 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2GLAHSD17B10CA12CA1 | |
| Bicarbonate SCHEMBL28234592 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2GLAHSD17B10CA12CA1 | |
| Propionic Acid SCHEMBL25192953 | 0.85 | GLA (0.50) | SMN1; SMN2GLAHSD17B10ALDH1A1KMT2A | |
| SCHEMBL16569982 | 0.85 | ALDH1A1 (0.44) | SMN1; SMN2GLAHSD17B10ALDH1A1TSHR | |
| Methyl Alcohol SCHEMBL28612959 | 0.85 | — | — | |
| SCHEMBL1221354 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110475783-A | Cationic ruthenium complex and preparation method thereof with and application thereof | TAKASAGO PERFUMERY CO LTD | 2019-11-19 | — | — | CN | disclosed |
| EP-0644196-B1 | TTTr as a protecting group in nucleotide synthesis | CIBA GEIGY AG (CH) | 1997-11-05 | — | — | EP | disclosed |
| CN-1111249-A | TTTr as protective group in nucleotide synthesis | CIBA GEIGY AG (CH) | 1995-11-08 | — | — | CN | disclosed |
| EP-0644196-A1 | TTTr as a protecting group in nucleotide synthesis | CIBA-GEIGY AG (CH) | 1995-03-22 | — | — | EP | disclosed |