Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.48 |
| ▸ | RXRB | P28702 | 13/20 | 0.48 |
| ▸ | RXRG | P48443 | 11/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | RARG | P13631 | 4/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881525 | 0.93 | RXRA (0.48) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7876894 | 0.92 | RXRA (0.51) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7885930 | 0.86 | RXRA (0.50) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7876906 | 0.85 | RXRA (0.51) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7876901 | 0.84 | RXRA (0.50) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7876764 | 0.84 | RXRA (0.50) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7876753 | 0.84 | RXRA (0.50) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7881549 | 0.84 | RXRA (0.50) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7881507 | 0.84 | RXRA (0.52) | RXRARXRBRXRGCYP26A1CYP3A4 | |
| SCHEMBL7876804 | 0.82 | RXRA (0.55) | RXRARXRBRXRGCYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728739-B1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CIRD GALDERMA (FR) | 1997-11-05 | — | — | EP | disclosed |
| EP-0728739-A1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-08-28 | — | — | EP | disclosed |