SCHEMBL8773658

SCHEMBL8773658

CC(C)(C)N(NC(=O)c1ccccc1)C(=O)c1ccc(F)cc1

nearest known ligand 0.82

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.82
CYP3A4 P08684 1/20 0.71
CYP2C9 P11712 1/20 0.71
RECQL P46063 1/20 0.69
HPGD P15428 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8773661 1.00 POLB (0.82) POLBCYP3A4CYP2C9RECQLHPGD
SCHEMBL9714384 0.94 POLB (0.71) POLBCYP3A4CYP2C9RECQLHPGD
Rh-5849 SCHEMBL1538531 0.91 POLB (1.00) POLBCYP3A4CYP2C9HPGDSMN1; SMN2
SCHEMBL9714390 0.88 POLB (0.63) POLBCYP3A4CYP2C9RECQLHPGD
SCHEMBL9714385 0.88 POLB (0.63) POLBCYP3A4CYP2C9RECQLHPGD
SCHEMBL10721036 0.88 POLB (0.63) POLBCYP3A4CYP2C9RECQLHPGD
SCHEMBL8167374 0.88 POLB (0.88) POLBCYP3A4CYP2C9HPGDSMN1; SMN2
SCHEMBL10720371 0.87 POLB (0.75) POLBCYP3A4CYP2C9RECQL
Hydrochloric Acid SCHEMBL8180262 0.87 POLB (0.61) POLBCYP3A4CYP2C9RECQLHPGD
SCHEMBL9714577 0.87 POLB (0.80) POLBCYP3A4CYP2C9HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630568-B1 Method of controlling insects ROHM & HAAS (US) 1997-09-10 EP claimed
EP-0630568-A1 Method of controlling insects ROHM AND HAAS COMPANY (US) 1994-12-28 EP claimed
US-5358966-A Using n,n'-diacylhydrazine ROHM AND HAAS COMPANY (US) 1994-10-25 US claimed
US-4985461-A Insecticidal N'-substituted-N,N'-diacylhydrazines ROHM AND HAAS COMPANY (US) 1991-01-15 US claimed
EP-0630568-B1 Method of controlling insects ROHM & HAAS (US) 1997-09-10 EP disclosed
EP-0630568-A1 Method of controlling insects ROHM AND HAAS COMPANY (US) 1994-12-28 EP disclosed
US-5358966-A Using n,n'-diacylhydrazine ROHM AND HAAS COMPANY (US) 1994-10-25 US disclosed
EP-0245950-B1 INSECTICIDAL N-SUBSTITUTED-N' - SUBSTITUTED-N, N'-DIACYLHYDRAZINES ROHM AND HAAS COMPANY (US) 1992-06-17 EP disclosed
EP-0236618-B1 INSECTICIDAL N'-SUBSTITUTED-N,N'-DIACYLHYDRAZINES ROHM AND HAAS COMPANY (US) 1991-02-27 EP disclosed
US-4985461-A Insecticidal N'-substituted-N,N'-diacylhydrazines ROHM AND HAAS COMPANY (US) 1991-01-15 US disclosed
EP-0236618-A2 Insecticidal N'-substituted-N,N'-diacylhydrazines ROHM AND HAAS COMPANY (US) 1987-09-16 EP disclosed