Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 15/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842649 | 0.89 | LTA4H (0.57) | LTA4HHRH3 | |
| SCHEMBL4842637 | 0.89 | LTA4H (0.57) | LTA4HHRH3 | |
| SCHEMBL4975539 | 0.89 | LTA4H (0.57) | LTA4HHRH3 | |
| SCHEMBL13809106 | 0.81 | LTA4H (0.76) | LTA4H | |
| SCHEMBL7326422 | 0.81 | LTA4H (0.76) | LTA4H | |
| Hydrochloric Acid SCHEMBL7323937 | 0.80 | LTA4H (0.74) | LTA4H | |
| Hydrochloric Acid SCHEMBL4319150 | 0.80 | LTA4H (0.74) | LTA4H | |
| SCHEMBL3495293 | 0.77 | LTA4H (0.51) | LTA4HHRH3 | |
| SCHEMBL7331063 | 0.76 | HRH1 (0.60) | LTA4HHRH1 | |
| SCHEMBL8192012 | 0.76 | LTA4H (0.64) | LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |