Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774188 | 1.00 | RXRA (0.33) | RXRAGRIN1GRIN2BTRPV3DHODH | |
| SCHEMBL8774166 | 0.88 | CYP2C9 (0.41) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL8774158 | 0.88 | CYP2C9 (0.41) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL17156238 | 0.86 | KDM4E (0.40) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL8774983 | 0.85 | MEN1 (0.37) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL8774988 | 0.85 | MEN1 (0.37) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL8774474 | 0.84 | CYP2C9 (0.39) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL8774438 | 0.84 | MAPT (0.39) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL8774494 | 0.84 | CYP2C9 (0.39) | RXRAGRIN1GRIN2BDHODHADRB3 | |
| SCHEMBL8774484 | 0.84 | CYP2C9 (0.39) | RXRAGRIN1GRIN2BDHODHADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |