Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774410 | 1.00 | GPR84 (0.36) | GPR84MAOBMAOAGRIN2BGRIN1 | |
| SCHEMBL8775102 | 0.93 | RARB (0.38) | GPR84MAOBMAOAGRIN2BGRIN1 | |
| SCHEMBL8775108 | 0.93 | RARB (0.38) | GPR84MAOBMAOAGRIN2BGRIN1 | |
| SCHEMBL8774175 | 0.92 | GRIN2B (0.37) | GPR84MAOBMAOAGRIN2BGRIN1 | |
| SCHEMBL8774171 | 0.92 | GRIN2B (0.37) | GPR84MAOBMAOAGRIN2BGRIN1 | |
| SCHEMBL8774710 | 0.91 | RARB (0.40) | GPR84MAOBMAOAGRIN2BGRIN1 | |
| SCHEMBL8774717 | 0.91 | RARB (0.40) | GPR84MAOBMAOAGRIN2BGRIN1 | |
| SCHEMBL8774659 | 0.90 | RARB (0.42) | GPR84RARBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8774711 | 0.90 | RARB (0.42) | GPR84RARBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8774668 | 0.90 | RARB (0.42) | GPR84RARBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |