Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774421 | 1.00 | TRPV3 (0.36) | TRPV3FASNS1PR4S1PR1S1PR5 | |
| SCHEMBL8774806 | 0.90 | CYP2C9 (0.41) | TRPV3FASNS1PR4S1PR1S1PR5 | |
| SCHEMBL8774680 | 0.88 | MEN1 (0.35) | — | |
| SCHEMBL8774687 | 0.88 | MEN1 (0.35) | — | |
| SCHEMBL11115196 | 0.87 | CYP2C9 (0.36) | TRPV3FASNKDM5AKDM4CKDM5B | |
| SCHEMBL11115194 | 0.87 | CYP2C9 (0.36) | TRPV3FASNKDM5AKDM4CKDM5B | |
| SCHEMBL9160322 | 0.87 | TRPV3 (0.34) | TRPV3FASNS1PR4S1PR1S1PR5 | |
| SCHEMBL9160310 | 0.87 | TRPV3 (0.34) | TRPV3FASNS1PR4S1PR1S1PR5 | |
| SCHEMBL8775186 | 0.87 | MAPT (0.37) | S1PR1 | |
| SCHEMBL8775182 | 0.87 | MAPT (0.37) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |