Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 14/20 | 0.54 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774490 | 1.00 | SPHK1 (0.54) | SPHK1SPHK2HTR2ARARBRARA | |
| SCHEMBL8774869 | 0.96 | SPHK1 (0.49) | SPHK1SPHK2 | |
| SCHEMBL8774873 | 0.96 | SPHK1 (0.49) | SPHK1SPHK2 | |
| SCHEMBL8775009 | 0.91 | SPHK1 (0.42) | SPHK1SPHK2 | |
| SCHEMBL8775016 | 0.91 | SPHK1 (0.42) | SPHK1SPHK2 | |
| SCHEMBL8774633 | 0.89 | SPHK1 (0.51) | SPHK1SPHK2HTR2ARARBRARA | |
| SCHEMBL8774650 | 0.89 | SPHK1 (0.51) | SPHK1SPHK2HTR2ARARBRARA | |
| SCHEMBL8774331 | 0.88 | SPHK1 (0.39) | SPHK1SPHK2HTR2A | |
| SCHEMBL8774341 | 0.88 | SPHK1 (0.39) | SPHK1SPHK2HTR2A | |
| SCHEMBL8774570 | 0.85 | SPHK1 (0.35) | SPHK1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |